IPD-IMGT/HLA Allele Ancestry Tool
This tool allows you to retrieve information on the reported ethnicity of individuals for whom allele sequences have been submitted to the IPD-IMGT/HLA Database. To search enter the start of the allele name (i.e.; A*, A*01, A*01:01:01:01, and any previous designations). The search tool will then retrieve all relevant hits. Wildcards will automatically be added to the search and the search tool is not case sensitive.
Recoding of IPD Ethnicities
The IPD-IMGT/HLA and IPD-KIR Sequence Databases have long maintained information on the source material each allele is derived from. This meta-data includes a description of the ethnicity, race or ancestry of the individual. The descriptive terms used were originally developed over 20 years, and whilst all efforts were made to make sure the terms listed were acceptable, we realise that society has changed and the descriptions used have become out-dated. For this reason, all terminology used in the IPD project has been reviewed and updated to utilise the Human Ancestry Ontology published in Genome Biology (https://rdcu.be/c6ZVu) and available at https://www.ebi.ac.uk/ols/ontologies/hancestro. From Release 3.52.0 of the IPD-IMGT/HLA Database onwards all descriptions will align with the Hancestro ontology. Previous designations will only be available from the Release archives held within our Git Hub Repositories. The IPD-KIR Database will be updated shortly after IPD-IMGT/HLA and prior to the release of Release 2.13 of the database.
For more information on use of the IPD-IMGT/HLA Allele Ancestry Tool and ancestry encoding in IPD please see our Ancestry Help Page
References:
- Morales, J., Welter, D., Bowler, E.H. et al.
A standardized framework for representation of ancestry data in genomics studies, with application to the NHGRI-EBI GWAS Catalog
Genome Biol (2018) 19:21.