Non-Human Primates

Welcome to the NHP database, a specialist database for the Major Histocompatibility Complex genes of Non-Human Primates. The database includes Apes and both Old World and New World monkeys. It presently covers over 51 different primate species and is subject to quality control. Incorporated in the database are currently known and annotated (full-length, or minimal exons 2 and 3) MHC class I sequences, and (full-length, or minimal exon 2) MHC class II sequences.

Alleles

List all Non-Human Primates alleles

Species

Species belonging to the Non-Human Primates group

Align

Multi locus inter- and intra- species alignment

Nomenclature

The nomenclature guidelines for the non-human primate MHCs were published in 1990 (Klein J. et al., 1990), and are still valid. Recent implemented nomenclature revisions for non-human primates are described in the 2012 nomenclature report (de Groot N.G. et al., 2012).

For allele designation the database uses the 2010 nomenclature rules described by the WHO Nomenclature Committee for Factors of the HLA System. When these are not adequate, the non-human primate specific nomenclature is introduced.

Mafa-B

971

Class I

Mamu-B

828

Class I

Mafa-A1

353

Class I

Mane-B

287

Class I

Mamu-A1

276

Class I

Mafa-DRB

185

Class II

Paan-B

145

Class I

Mafa-I

138

Class I

Mamu-DRB

130

Class II

Mafa-DPB1

115

Class II

Above are listed the most populated genes within the Non-Human Primates group. To list all the genes within the NHP taxonomic group, please visit the species page.

Search NHP alleles

Group curator

Dr. Natasja de Groot - groot [at] bprc.nl

Biomedical Primate Research Centre, Department of Comparitive Genetics and Refinement, Netherlands

References

Please cite the IPD-MHC NHP database whenever you publish your sequences. When citing the database you can use the following articles.

  • Maccari G, Robinson J, Ballingall K, Guethlein LA, Grimholt U, Kaufman J, Ho CS, De Groot NG, Flicek P, Bontrop RE, Hammond JA and Marsh SGE IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex. Nucleic Acids Res. (2017), 45: D860–D864
  • Robinson J, Waller MJ, Stoehr P, Marsh SGE IPD-the Immuno Polymorphism Database Nucleic Acids Research (2013) 41:D1222-7
  • de Groot NG, Otting N, Robinson J, Blancher A, Lafont BAP, Marsh SGE, O'Connor DH, Shiina T, Walter L, Watkins DI, Bontrop RE Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species Immunogenetics (2012), 64 (8): 615-631
  • de Groot NG, Otting N, Maccari G, Robinson J, Hammond JA, Blancher A, Lafont BAP, Guethlein LA, Wroblewski EE, Marsh SGE, Shiina T, Walter L, Vigilant L, Parham P, O’Connor DH, Bontrop RE Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species. Immunogenetics 2020, 72(1-2): 37-47