KIR Ligand Calculator
Recent transplant strategies based on KIR-ligand mismatch have resulted in less relapse, less GvHD and better overall survival in patients with Acute Myeloid Leukaemia (AML) (1). KIR-ligands can be grouped into three major categories based on the KIR-binding epitope in HLA-C and HLA-B. Most HLA-C alleles are of the C1 or C2 group (2) and most HLA-B alleles can be classified as either Bw4 or Bw6 (3). For more information on the use of the KIR Ligand Calculator please see our help pages
- Enter the two field typings in the box provided. For example for an individual typed as B*07:02, B*08:01, C*07:01, C*07:02, you would enter 07:02 in the first box, 08:01 in the second box and so on.
- If an individual is homozygous for a locus enter the typing in all boxes. Do not leave a box blank.
- Null alleles are not expressed so please do not enter null alleles into the box provided.
- Two field typing is required.
References
- Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K, Urbani E, Negrin RS, Martelli MF, Velardi A.
Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation.
Blood (1999) 91:333-9 (Abstract) - Khakoo SI, Thio CL, Martin MP, Brooks CR, Gao X, Astemborski J, Cheng J, Goedert JJ, Vlahov D, Hilgartner M, Cox S, Little AM, Alexander GJ, Cramp ME, O'Brien SJ, Rosenberg WM, Thomas DL, Carrington M.
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.
Science (2004) 305:872-4 (Abstract) - Gumperz JE, Barber LD, Valiante NM, Percival L, Phillips JH, Lanier LL, Parham P.
Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor.
Journal of Immunology. (1997) 158:5237-41 (Abstract)