HLA-B Leader Mismatch Calculator
It has been show that in HLA-B, the leader sequence encodes methionine (M) or threonine (T) at position -21 and can give rise to TT, MT, or MM genotypes. The dimorphic HLA-B leader sequence informs graft-versus-host disease (GVHD) risk in HLA-B mismatched Haematopoietic cell transplantation (HCT). In HLA-B mismatched unrelated HCT, the risk of acute GVHD is higher when the patient has an M in the leader sequence and when the the leader sequence is mismatched (Petersdorf et al. 2020).
This tool allows patient and donor HLA-B types to be compared for mismatches in the leader sequences.
- Please enter a valid HLA-B typing using the numerical allele code only, for example HLA-B*07:02:01 would be entered as '07:02:01'
- Ambiguous typings are not permitted and all alleles should be defined to at least two fields; i.e. '07:02' and not '07'.
- In cases of apparent homozygosity, the typing should be entered in both boxes, or an error will be reported
- In the case of null alleles, these will be treated as homozygous for the expressed allele.
Disclaimer - This tool is being offered to predict HLA-B Leader matching as reported in Petersdorf et al. 2020
No information entered into this tool is collected or stored on our servers.
References
- Petersdorf EW, Stevenson P, Bengtsson M, De Santis D, Dubois V, Gooley T, Horowitz M, Hsu K, Madrigal JA, Malkki M, McKallor C, Morishima Y, Oudshoorn M, Spellman SR, Villard J, Carrington M.
HLA-B leader and survivorship after HLA-mismatched unrelated donor transplantation.
Blood (2020) 136:362-9
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API
An API has been developed for this tool, please see our API Documentation for further details