IPD-IMGT/HLA

• IPD
• IMGT/HLA
• Matching

IMGT/HLA and IPD-KIR Matching Algorithms

The IPD-IMGT/HLA and IPD-KIR Databases provide a number of tools based on published matching algorithms. These have been developed in collaboration with the authors of the original papers, with the aim of providing a user friendly interface to aid in HLA matching of potential donor with a patient. New tools are being developed and APIs added to the existing tools to better enable programmatical interfaces.

DPB1 T-Cell Epitope Algorithms

Classification of HLA-DPB1 mismatches based on T-cell-epitope Groups (TCE-Groups) has been shown to identify mismatches that might be tolerated (permissive) and those that would increase risks (non-permissive) after unrelated-donor haematopoietic stem cell transplantation (HSCT). These calculators allows you to enter the HLA-DPB1 typing of a patient and donor and view the predicted T-Cell epitopes and resulting prediction of the effect of mismatching when selecting appropriate donors for HSCT recipients (Fleischhauer, 2012).

HLA-B Leader Matching

Haematopoietic cell transplantation (HCT) from HLA-mismatched unrelated donors can cure life-threatening blood disorders, but its success may be limited by graft-versus-host disease (GVHD). The dimorphic HLA-B leader sequence informs GVHD risk in HLA-B–mismatched HCT (Petersdorf, 2020). This tool allows the patient and donor HLA-B types to be compared for mismatches in the leader sequences.

KIR Ligand Calculator

Recent transplant strategies based on KIR-ligand mismatch to predict NK cell alloreactivity have resulted in less relapse, less GvHD and better overall survival in patients with Acute Myeloid Leukaemia (Ruggeri, 1999).

KIR Donor B-Content Calculator

Group A and B KIR haplotypes have distinctive centromeric (Cen) and telomeric (Tel) gene-content motifs. With the goal of developing a donor selection strategy to improve transplant outcome, Cooley et al., compared the contribution of these motifs to the clinical benefit conferred by B haplotype donors (Cooley, 2010).

HLA Matching APIs

APIs have been developed for a number of the matching tools and documentation can be found on the following page;

CE Marking, MHRA and MDR compliance

The matching algorithms available on the IPD websites are classified as decision support software, they provide reference information to enable a healthcare professional (HCP) to make a clinical decision, where the HCP ultimately rely on their own knowledge and expertise to decide on the treatment option for their patient. The algorithms will filter the data for the healthcare professional to review, the raw data will always need to be reviewed and any reported results are calculated based on algorithms implemented from peer-reviewed published papers. The results could be reproduced manually but the tools allow for a faster analysis time, and analysis of multiple patient and donor combinations at the same time. For this reason, this software is not considered as a medical device under regulation The United Kingdom Medical Devices Regulation 2002 (UK MDR 2002).

References

• Fleischhauer K, Shaw BE, Gooley T, et al.
  Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.
  Lancet Oncology (2012) 13:366-74
• Petersdorf EW, Stevenson P, Bengtsson M, De Santis D, Dubois V, Gooley T, Horowitz M, Hsu K, Madrigal JA, Malkki M, McKallor C, Morishima Y, Oudshoorn M, Spellman SR, Villard J, Carrington M.
  HLA-B leader and survivorship after HLA-mismatched unrelated donor transplantation.
  Blood (2020) 136:362-9
• Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K, Urbani E, Negrin RS, Martelli MF, Velardi A.
  Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation.
  Blood (1999) 91:333-9