DPB1 T-Cell Epitope Algorithm v2.0
Classification of HLA-DPB1 mismatches based on T-cell-epitope Groups (TCE-Groups) has been shown to identify mismatches that might be tolerated (permissive) and those that would increase risks (non-permissive) after unrelated-donor haematopoietic stem cell transplantation (HSCT). This calculator allows you to enter the HLA-DPB1 typing of a patient and donor and view the predicted T-Cell epitopes and resulting prediction of the effect of mismatching when selecting appropriate donors for HSCT recipients.
The tool has been updated following the recent publication;
- Crivello P, Zito L, Sizzano F, et al.
The Impact of Amino Acid Variability on Alloreactivity Defines a Functional Distance Predictive of Permissive HLA-DPB1 Mismatches in Hematopoietic Stem Cell Transplantation
Biol Blood Marrow Transplant (2015) 21:233-41.
The TCE group assignment is reported for all DPB1 alleles according to Release 3.38.0 of the IPD-IMGT/HLA Database, released 2019-10.
The following syntax is used:
- The suffix 'a' is added to the TCE group of 4 alleles to indicate that they were reclassified in the Crivello et al. 2015 paper. These alleles are DPB1*06:01, DPB1*08:01, DPB1*19:01 and DPB1*106:01.
- The suffix '$' is added to the TCE group to indicate those alleles that were assigned by functional distance scores only.
The implementation of the DPB1 T-Cell Epitope algorithm has been written in collaboration with Katharina Fleischhauer, University Hospital Essen, Germany and Bronwen Shaw, CIBMTR, USA. Regular updates of the DPB1 T-Cell Epitope algorithm with new alleles are performed in collaboration with Pietro Crivello, University Hospital Essen, Germany.
Disclaimer - This tool is being offered as a tool to predict T-Cell epitope matching at DPB1 as reported in:
- Crivello P, Zito L, Sizzano F, et al.
The Impact of Amino Acid Variability on Alloreactivity Defines a Functional Distance Predictive of Permissive HLA-DPB1 Mismatches in Hematopoietic Stem Cell Transplantation
Biol Blood Marrow Transplant (2015) 21:233-41. - Fleischhauer K, Shaw BE, Gooley T, et al.
Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.
Lancet Oncology (2012) 13:366-74 - Crocchiolo R, Zino E, Vago L, et al.
Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation.
Blood (2009) 114:1437-44. - Zino E, Vago L, Di Terlizzi S, et al.
Frequency and targeted detection of HLA-DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation.
Biol Blood Marrow Transplant (2007) 13:1031-40. - Zino E, Frumento G, Marktel S, et al.
A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation.
Blood (2004) 103:1417-24.
No information entered into this tool is collected or stored on our servers.
API
An API has been developed for this tool, please see our API Documentation for further details